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Adenocarcinoma

MedGen UID:
122
•Concept ID:
C0001418
•
Neoplastic Process
Synonyms: Adenocarcinomas; Adenoma, Malignant; Adenomas, Malignant; Malignant Adenoma; Malignant Adenomas
SNOMED CT: Adenocarcinoma (1187332001)
 
Monarch Initiative: MONDO:0004970

Definition

A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma

Professional guidelines

PubMed

International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas.
Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

Recent clinical studies

Etiology

Updates on lung adenocarcinoma: invasive size, grading and STAS.
Willner J, Narula N, Moreira AL
Histopathology 2024 Jan;84(1):6-17. Epub 2023 Oct 23 doi: 10.1111/his.15077. PMID: 37872108
Amino acids and risk of colon adenocarcinoma: a Mendelian randomization study.
Wang Y, Jia Z, Wang Q, Zhu Z
BMC Cancer 2023 Oct 28;23(1):1041. doi: 10.1186/s12885-023-11514-w. PMID: 37898769Free PMC Article
The 5(th) edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma.
Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Pancreatic Cancer.
Moore A, Donahue T
JAMA 2019 Oct 8;322(14):1426. doi: 10.1001/jama.2019.14699. PMID: 31593274Free PMC Article

Diagnosis

Sinonasal Adenocarcinomas: An Update.
Arcovito G, Franchi A
Surg Pathol Clin 2024 Dec;17(4):653-666. Epub 2024 Aug 17 doi: 10.1016/j.path.2024.07.005. PMID: 39489555
Amino acids and risk of colon adenocarcinoma: a Mendelian randomization study.
Wang Y, Jia Z, Wang Q, Zhu Z
BMC Cancer 2023 Oct 28;23(1):1041. doi: 10.1186/s12885-023-11514-w. PMID: 37898769Free PMC Article
Sebaceous Carcinoma.
Erickson LA
Mayo Clin Proc 2021 Aug;96(8):2285-2287. doi: 10.1016/j.mayocp.2021.06.009. PMID: 34353478
Historical Evolution of the Polymorphous Adenocarcinoma.
Hernandez-Prera JC
Head Neck Pathol 2019 Sep;13(3):415-422. Epub 2018 Sep 5 doi: 10.1007/s12105-018-0964-9. PMID: 30187348Free PMC Article
Adenocarcinoma of the pancreas.
Hruban RH, Klimstra DS
Semin Diagn Pathol 2014 Nov;31(6):443-451. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.004. PMID: 25441308Free PMC Article

Therapy

Association of PD-L1 Expression and Other Variables With Benefit From Immune Checkpoint Inhibition in Advanced Gastroesophageal Cancer: Systematic Review and Meta-analysis of 17 Phase 3 Randomized Clinical Trials.
Yoon HH, Jin Z, Kour O, Kankeu Fonkoua LA, Shitara K, Gibson MK, Prokop LJ, Moehler M, Kang YK, Shi Q, Ajani JA
JAMA Oncol 2022 Oct 1;8(10):1456-1465. doi: 10.1001/jamaoncol.2022.3707. PMID: 36006624Free PMC Article
MATTERHORN: phase III study of durvalumab plus FLOT chemotherapy in resectable gastric/gastroesophageal junction cancer.
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs.
Milano G, Innocenti F, Minami H
Cancer Sci 2022 Jul;113(7):2224-2231. Epub 2022 May 26 doi: 10.1111/cas.15377. PMID: 35445479Free PMC Article
Immunotherapy for pancreatic ductal adenocarcinoma.
Carpenter E, Nelson S, Bednar F, Cho C, Nathan H, Sahai V, di Magliano MP, Frankel TL
J Surg Oncol 2021 Mar;123(3):751-759. doi: 10.1002/jso.26312. PMID: 33595893
Cabozantinib in genitourinary malignancies.
Zhang T, Park SE, Hong C, George DJ
Future Oncol 2017 Apr;13(8):755-765. Epub 2016 Nov 15 doi: 10.2217/fon-2016-0358. PMID: 27842445

Prognosis

Burden of Pancreatic Cancer: From Epidemiology to Practice.
Khalaf N, El-Serag HB, Abrams HR, Thrift AP
Clin Gastroenterol Hepatol 2021 May;19(5):876-884. Epub 2020 Mar 6 doi: 10.1016/j.cgh.2020.02.054. PMID: 32147593Free PMC Article
Physical Activity in Cancer Prevention and Survival: A Systematic Review.
McTiernan A, Friedenreich CM, Katzmarzyk PT, Powell KE, Macko R, Buchner D, Pescatello LS, Bloodgood B, Tennant B, Vaux-Bjerke A, George SM, Troiano RP, Piercy KL; 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*
Med Sci Sports Exerc 2019 Jun;51(6):1252-1261. doi: 10.1249/MSS.0000000000001937. PMID: 31095082Free PMC Article
Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study.
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article
Pediatric Thyroid Microcarcinoma.
Lerner J, Goldfarb M
Ann Surg Oncol 2015 Dec;22(13):4187-92. Epub 2015 Apr 9 doi: 10.1245/s10434-015-4546-8. PMID: 25854844
The epidemic of esophageal adenocarcinoma.
el-Serag HB
Gastroenterol Clin North Am 2002 Jun;31(2):421-40, viii. doi: 10.1016/s0889-8553(02)00016-x. PMID: 12134611

Clinical prediction guides

Clinical Risk Prediction Model for Neoadjuvant Therapy in Resectable Esophageal Adenocarcinoma.
Thota PN, Alkhayyat M, Gomez Cifuentes JD, Haider M, Bena J, McMichael J, Sohal DP, Raja S, Sanaka MR
J Clin Gastroenterol 2022 Feb 1;56(2):125-132. doi: 10.1097/MCG.0000000000001489. PMID: 33405434Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.
Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920Free PMC Article
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179
Current State of ERG as Biomarker in Prostatic Adenocarcinoma.
Acs B, Szarvas T, Szekely N, Nyirady P, Szasz AM
Curr Cancer Drug Targets 2015;15(8):643-51. doi: 10.2174/156800961508151001100829. PMID: 26452381
Risk stratification in extramammary Paget disease.
Cohen JM, Granter SR, Werchniak AE
Clin Exp Dermatol 2015 Jul;40(5):473-8. Epub 2015 May 26 doi: 10.1111/ced.12690. PMID: 26011765

Recent systematic reviews

Oral contraceptives use and risk of cervical cancer-A systematic review & meta-analysis.
Asthana S, Busa V, Labani S
Eur J Obstet Gynecol Reprod Biol 2020 Apr;247:163-175. Epub 2020 Feb 21 doi: 10.1016/j.ejogrb.2020.02.014. PMID: 32114321
Differentiated Thyroid Cancer-Treatment: State of the Art.
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article
Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.
Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P, Forastiere F, Saldiva P, Yorifuji T, Loomis D
Environ Health Perspect 2014 Sep;122(9):906-11. Epub 2014 Jun 6 doi: 10.1289/ehp/1408092. PMID: 24911630Free PMC Article
Stomach cancer.
Bailey C
BMJ Clin Evid 2011 Mar 28;2011 PMID: 21439098Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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